Reactome: A Curated Pathway Database

(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA]

Stable Identifier
R-HSA-74241
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
adenosine deaminase activity of ADA [cytosol] ADA [cytosol] adenosine deaminase activity (0004000)
Orthologous Events
Cross References
Rhea