Reactome: A Curated Pathway Database

(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA] (R-HSA-74241)

Species Homo sapiens


Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.

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Compartment cytosol
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Catalyst Activity
PhysicalEntity Activity Active Units
ADA adenosine deaminase activity (0004000)
Literature References
pubMedId Title Journal Year
3182793 Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts J Biol Chem 1988