Reactome: A Curated Pathway Database

(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]

Stable Identifier
R-HSA-74242
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of inosine or deoxyinosine with orthophosphate to form hypoxanthine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either nuckeotide in vitro, levels of deoxyinosine are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
purine-nucleoside phosphorylase activity of NP trimer [cytosol] NP trimer [cytosol] purine-nucleoside phosphorylase activity (0004731)
Orthologous Events