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(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)

Stable Identifier
R-HSA-74249
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either nuckeotide in vitro, levels of deoxyguanosine are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
purine-nucleoside phosphorylase activity of NP trimer [cytosol]
Physical Entity
Activity
Orthologous Events