Reactome: A Curated Pathway Database

(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP] (R-HSA-74249) [Homo sapiens]


Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either nuckeotide in vitro, levels of deoxyguanosine are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
NP trimer purine-nucleoside phosphorylase activity (0004731)