Reactome: A Curated Pathway Database

Purine catabolism (R-HSA-74259) [Homo sapiens]


The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.

Additional Information
GO Biological Process purine nucleotide catabolic process (0006195)
Cross References
Database Identifier
BioModels Database BIOMD0000000015
Literature References
pubMedId Title Journal Year
4620886 Molecular variation in relation to purine metabolism J Clin Pathol Suppl (R Coll Pathol) 1974