Reactome: A Curated Pathway Database
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The Ligand:GPCR:Gs complex dissociates

Stable Identifier
R-HSA-744886
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events