Reactome: A Curated Pathway Database

Phosphorylation of IRS

Stable Identifier
R-HSA-74711
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'IRS:activated insulin receptor' are present. At the end of this reaction, 1 molecule of 'phospho-IRS:activated insulin receptor', and 1 molecule of 'ADP' are present.

This reaction takes place on the 'internal side of plasma membrane' and is mediated by the 'transmembrane receptor protein tyrosine kinase activity' of 'IRS:activated insulin receptor'.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
transmembrane receptor protein tyrosine kinase activity of IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] transmembrane receptor protein tyrosine kinase activity (0004714)
Orthologous Events