Reactome: A Curated Pathway Database

Insulin degradation (R-HSA-74730) [Homo sapiens]

Black Box Event

At the beginning of this reaction, 1 molecule of 'insulin' is present.

This reaction takes place in the 'endosome' and is mediated by the 'insulysin activity of IDA (insulin degrading activity' of 'IDA (insulin degrading activity)'.

Additional Information
Compartment endosome
Components of this entry
Input entries
Catalyst Activity
PhysicalEntity Activity Active Units
IDA endopeptidase activity (0004175)  
Literature References
pubMedId Title Journal Year
3061785 Insulin degradation: mechanisms, products, and significance. Endocr Rev 1989
9793760 Insulin degradation: progress and potential. Endocr Rev 1998
8682206 Endosomal proteolysis of internalized proteins. FEBS Lett 1996