Reactome: A Curated Pathway Database

Signal attenuation (R-HSA-74749) [Homo sapiens]

Pathway
Summation

Now with the complete receptor-ligand dissociation and subsequent degradation of insulin in the endosomal lumen, the endosomally associated protein tyrosine phosphatases (PTPs) complete the receptor dephosphorylation. So too are all the receptor substrates dephosphorylated leading to the collapse of the signalling complexes and signal attenuation.

Additional Information
Compartment cytosol
Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000466, BIOMD0000000424