Reactome: A Curated Pathway Database

Signal attenuation

Stable Identifier
R-HSA-74749
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Now with the complete receptor-ligand dissociation and subsequent degradation of insulin in the endosomal lumen, the endosomally associated protein tyrosine phosphatases (PTPs) complete the receptor dephosphorylation. So too are all the receptor substrates dephosphorylated leading to the collapse of the signalling complexes and signal attenuation.

Participants
Participant Of
Orthologous Events
Cross References