Reactome: A Curated Pathway Database

Signal attenuation (R-HSA-74749)

Species Homo sapiens


Now with the complete receptor-ligand dissociation and subsequent degradation of insulin in the endosomal lumen, the endosomally associated protein tyrosine phosphatases (PTPs) complete the receptor dephosphorylation. So too are all the receptor substrates dephosphorylated leading to the collapse of the signalling complexes and signal attenuation.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000466, BIOMD0000000424