Reactome: A Curated Pathway Database

Insulin receptor signalling cascade (R-HSA-74751)

Species Homo sapiens


Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Literature References
pubMedId Title Journal Year
11282018 Insulin signalling. J Cell Sci 2001
9677303 Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998