Insulin receptor signalling cascade

Stable Identifier
R-HSA-74751
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.

Literature References
PubMed ID Title Journal Year
9677303 Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998
11282018 Insulin signalling. J Cell Sci 2001
Participants
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Orthologous Events