Reactome: A Curated Pathway Database

p-Y-IRS1 (R-HSA-74772) [Homo sapiens]

Reference Gene Product
Locations in the PathwayBrowser
Additional Information
External reference name IRS1
External reference id P35568
Synonyms p-IRS1, Insulin receptor substrate-1
Compartment cytosol
Other Identifiers
 0003850373  11743627_a_at  11743628_at  11743629_at  1IRS
 1K3A  1QQG  204686_at  242979_at  2Z8C
 3667  41049_at  75148_at  850_r_at  851_s_at
 872_i_at  A0A024R499  A_24_P225679  A_24_P802145  AAB21608
 AAB27175  AAH53895  BC053895  CAB005261  CCDS2463
 CH471063  EAW70838  EAW70839  ENSG00000169047  ENSP00000304895
 ENST00000305123  EntrezGene:3667  g5031804_3p_at  GE58787  HGNC:6125
 HPA046433  HPA050221  Hs.257786.0.A1_3p_at  Hs.471508  ILMN_1759232
 IPR001849  IPR002404  IPR011993  IRS1  IRS1-001
 MIM:147545  NM_005544  NP_005535  OTTHUMP00000164234  PF00169
 PF02174  PH_hs_0024522  PH_hs_0048800  PR00628  R-HSA-109704
 R-HSA-112399  R-HSA-112412  R-HSA-1168372  R-HSA-1227986  R-HSA-1236394
 R-HSA-1250196  R-HSA-1250342  R-HSA-1250347  R-HSA-1257604  R-HSA-1266738
 R-HSA-1280215  R-HSA-1280218  R-HSA-1433557  R-HSA-162582  R-HSA-1643685
 R-HSA-166520  R-HSA-167044  R-HSA-168249  R-HSA-168256  R-HSA-169893
 R-HSA-170968  R-HSA-170984  R-HSA-177929  R-HSA-179812  R-HSA-180292
 R-HSA-180336  R-HSA-186763  R-HSA-186797  R-HSA-187037  R-HSA-187687
 R-HSA-187706  R-HSA-190236  R-HSA-194138  R-HSA-1963640  R-HSA-1963642
 R-HSA-198203  R-HSA-2172127  R-HSA-2219528  R-HSA-2219530  R-HSA-2404192
 R-HSA-2424491  R-HSA-2428924  R-HSA-2428928  R-HSA-2454202  R-HSA-2586552
 R-HSA-2730905  R-HSA-2871796  R-HSA-372790  R-HSA-375165  R-HSA-422475
 R-HSA-4420097  R-HSA-449147  R-HSA-451927  R-HSA-512988  R-HSA-5218921
 R-HSA-5654687  R-HSA-5654689  R-HSA-5654693  R-HSA-5654695  R-HSA-5654696
 R-HSA-5654700  R-HSA-5654706  R-HSA-5654708  R-HSA-5654710  R-HSA-5654712
 R-HSA-5654716  R-HSA-5654720  R-HSA-5654736  R-HSA-5654738  R-HSA-5654741
 R-HSA-5654743  R-HSA-5663202  R-HSA-5673001  R-HSA-5683057  R-HSA-5684996
 R-HSA-74713  R-HSA-74749  R-HSA-74751  R-HSA-74752  R-HSA-881907
 R-HSA-912526  R-HSA-982772  R-HSA-983705  S62539  S62539_at
 S85963  SM00233  SM00310  uc002voh.5  UPI000003BB52
Secondary Identifiers IRS1_HUMAN
Gene Names IRS1
Chain chain:1-1242
This entry is a component of:
hasMember
Reference Genes
Database Identifier
dbSNP Gene 3667
CTD Gene 3667
BioGPS Gene 3667
NCBI Gene 3667
ENSEMBL ENSG00000169047
KEGG Gene IRS1
Reference Transcripts
Database Identifier
RefSeq NM_005544
Cross References
Database Identifier
RefSeq NP_005535
DOCK Blaster 1QQG, 2Z8C, 1IRS, 1K3A
PRO P35568
GeneCards P35568
UCSC human P35568
Protein Data Bank 1QQG, 2Z8C, 1IRS, 1K3A
ModifiedResidues
Name Coordinate Modification PsiMod Name PsiMod Identifier PsiMod Definition
O4'-phospho-L-tyrosine at unknown position O4'-phospho-L-tyrosine 00048 A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactions
Confidence Score Interactor Accession Interactor Name Evidence
0.921 P27986 P85A 13
0.755 P42336 PK3CA 21
0.704 P06213 INSR 5
0.682 P62258 1433E 6
0.57 Q92569 P55G 4
0.57 P27986-2 PIK3R1 3
0.57 O75815 BCAR3 3
0.508 P03495 NS1 I72A2 2
0.502 P09217 KPCZ RAT 2
0.499 P11940 PABP1 2
0.488 P49757 NUMB 2