Reactome: A Curated Pathway Database

p-Y-IRS1

Stable Identifier
R-HSA-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-IRS1, Insulin receptor substrate-1, IRS-1
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
IRS1
Chain
chain:1-1242
Reference Genes
Reference Transcript
Other Identifiers
 0003850373  11743627_a_at  11743628_at  11743629_at  16909165
 1IRS  1K3A  1QQG  204686_at  242979_at
 2602018  2602019  2602020  2602036  2602037
 2602038  2602039  2602040  2602041  2602042
 2602043  2602044  2602045  2602046  2602047
 2602048  2602049  2602050  2602073  2602074
 2602075  2602087  2Z8C  3667  41049_at
 5261  75148_at  8059470  850_r_at  851_s_at
 872_i_at  A0A024R499  A_24_P225679  A_24_P802145  AAB21608
 AAB27175  AAH53895  BC053895  CAB005261  CCDS2463
 CH471063  EAW70838  EAW70839  ENSG00000169047  ENSP00000304895
 ENST00000305123  g5031804_3p_at  GE58787  GO:0000165  GO:0001784
 GO:0003674  GO:0004871  GO:0005068  GO:0005080  GO:0005088
 GO:0005158  GO:0005159  GO:0005515  GO:0005575  GO:0005622
 GO:0005623  GO:0005634  GO:0005737  GO:0005829  GO:0005886
 GO:0005899  GO:0005901  GO:0005975  GO:0006091  GO:0006464
 GO:0006629  GO:0006810  GO:0007165  GO:0007267  GO:0008150
 GO:0008283  GO:0008284  GO:0008286  GO:0009056  GO:0009058
 GO:0010907  GO:0014065  GO:0014066  GO:0016301  GO:0016303
 GO:0019899  GO:0030674  GO:0032000  GO:0032868  GO:0032869
 GO:0036092  GO:0042169  GO:0042592  GO:0042593  GO:0043226
 GO:0043231  GO:0043434  GO:0043547  GO:0043548  GO:0043552
 GO:0044281  GO:0045725  GO:0046326  GO:0046627  GO:0046628
 GO:0046676  GO:0046854  GO:0046934  GO:0048009  GO:0048015
 GO:2001275  HGNC:6125  Hs.257786.0.A1_3p_at  Hs.471508  ILMN_1759232
 IPR001849  IPR002404  IPR011993  IRS1  IRS1-201
 MIM:125853  MIM:147545  NCBI Gene:3667  NM_005544  NP_005535
 PF00169  PF02174  PH_hs_0024522  PR00628  S62539
 S62539_at  S85963  SM00233  SM00310  SM01244
 TC02002830.hg  TC02004835.hg  uc002voh.5  UPI000003BB52
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name Coordinate Modification PsiMod
O4'-phospho-L-tyrosine at unknown position
O4'-phospho-L-tyrosine [MOD:00048] A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
UCSC human
GeneCards
DOCK Blaster
PRO
Protein Data Bank
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.921 P27986 P85A_HUMAN 13
0.755 P42336 PK3CA_HUMAN 21
0.704 P06213 INSR_HUMAN 5
0.682 P62258 1433E_HUMAN 6
0.57 Q92569 P55G_HUMAN 4
0.57 P27986-2 PIK3R1 3
0.57 O75815 BCAR3_HUMAN 3
0.508 P03495 NS1_I72A2 2
0.502 P09217 KPCZ_RAT 2
0.499 P11940 PABP1_HUMAN 2
0.488 P49757 NUMB_HUMAN 2