There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

The Ligand:GPCR:Gq complex dissociates

Stable Identifier
R-HSA-749452
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (q) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).

Literature References
PubMed ID Title Journal Year
18577758 Dissociation of heterotrimeric g proteins in cells Sci Signal 2008
Participants
Participant Of
Orthologous Events