Reactome: A Curated Pathway Database

The Ligand:GPCR:Gi complex dissociates (R-HSA-749454) [Homo sapiens]


The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (i) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).

Additional Information
Compartment extracellular region , plasma membrane
Literature References
pubMedId Title Journal Year
18577758 Dissociation of heterotrimeric g proteins in cells Sci Signal 2008