Reactome: A Curated Pathway Database

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

Stable Identifier
R-HSA-75035
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state. Cdc2 activity is regulated by a balance between the phosphorylation and dephosphorylation by the Wee1/Myt1 kinase and Cdc25 phosphatase. Inactivation of the Cyclin B:Cdc2 complex likely involves both inactivation of Cdc25 and/or stimulation of Wee1/Myt1 kinase activity.

Participants
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Orthologous Events