Reactome: A Curated Pathway Database

Intermolecular autophosphorylation of ATM within dimeric ATM complexes (R-HSA-75147)

Species Homo sapiens


ATM is present in unirradiated cells as a dimer or higher-order multimer. Following irradiation, ATM undergoes rapid intermolecular autophosphorylation of serine 1981.

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Additional Information
Compartment nucleoplasm
GO Biological Process protein autophosphorylation (0046777)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
dimeric ATM kinase protein serine/threonine kinase activity (0004674)
Literature References
pubMedId Title Journal Year
12556884 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 2003