Reactome: A Curated Pathway Database

Apoptotic execution phase (R-HSA-75153) [Homo sapiens]


In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003).

Cross References
Database Identifier
BioModels Database BIOMD0000000407, BIOMD0000000220
Literature References
pubMedId Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates Cell Death Differ 2003