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Apoptotic execution phase

Stable Identifier
R-HSA-75153
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003).

Literature References
PubMed ID Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates Cell Death Differ 2003
Participants
Participant Of
hasEvent
Event Information
Orthologous Events
Cross References
BioModels Database