ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1524 and S1547 (Cortez et al. 1999, Gatei et al. 2000). At least a fraction of these sites and some additional BRCA1 SQ/TQ sites can also be phosphorylated by ATR (Tibbetts et al. 2000). ATM also phosphorylates BARD1, the heterodimerization partner of BRCA1, at threonine residues T714 and T734 (Kim et al. 2006).
|p-S1981-ATM||protein serine/threonine kinase activity (0004674)|
|10550055||Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks||Science||1999|
|10866324||Role for ATM in DNA damage-induced phosphorylation of BRCA1||Cancer Res.||2000|
|11114888||Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress||Genes Dev.||2000|
|16651405||DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex||Cancer Res.||2006|