Reactome: A Curated Pathway Database

Phosphorylation of BRCA1 at multiple sites by ATM (R-HSA-75239)

Species Homo sapiens

Summation

ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1524 and S1547 (Cortez et al. 1999, Gatei et al. 2000). At least a fraction of these sites and some additional BRCA1 SQ/TQ sites can also be phosphorylated by ATR (Tibbetts et al. 2000). ATM also phosphorylates BARD1, the heterodimerization partner of BRCA1, at threonine residues T714 and T734 (Kim et al. 2006).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981-ATM protein serine/threonine kinase activity (0004674)
This entry is regulated by
Regulation type Name
PositiveRegulation