Reactome: A Curated Pathway Database

Phosphorylation of NBS1 by ATM (R-HSA-75241)

Species Homo sapiens

Summation

NSB1 is a component of the MRE11/RAD50/NBS1 complex which acts early in HRR during resection of the double-strand break. In addition, NBS1 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981-ATM protein serine/threonine kinase activity (0004674)
This entry is regulated by
Regulation type Name
PositiveRegulation