Reactome: A Curated Pathway Database

Phosphorylation of NBS1 by ATM (R-HSA-75241)

Species Homo sapiens


NSB1 is a component of the MRE11/RAD50/NBS1 complex which acts early in HRR during resection of the double-strand break. In addition, NBS1 is required for activation of the S-phase checkpoint in response to ionizing radiation (IR), ATM-dependent activation of CHK2 and cell survival after exposure to IR.

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Compartment nucleoplasm
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Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981-ATM protein serine/threonine kinase activity (0004674)
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