Reactome: A Curated Pathway Database

Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains) (R-HSA-75245)

Species Homo sapiens


ATM mediated phosphorylation of MDC1/NFBD1 may be involved in the rapid relocalization of MDC1/NFBD1 to nuclear foci that contain the MRE11 complex, phosphorylated histone H2AX and 53BP1 (Goldberg et al., 2003). NFBD1 may also function in recruiting DNA checkpoint signaling and repair proteins to the sites of DNA damage (Xu and Stern., 2003 and Stewart et al.,2003).

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
p-S1981-ATM protein serine/threonine kinase activity (0004674)
Cross References
Database Identifier
IntAct EBI-495607, EBI-495489
Literature References
pubMedId Title Journal Year
12607003 MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 2003