Reactome: A Curated Pathway Database

Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (R-HSA-75866) [Homo sapiens]


At the beginning of this reaction, 1 molecule of 'Pol II initiation complex' is present. At the end of this reaction, 1 molecule of 'Pol II Initiation complex with phosphodiester-PPi intermediate' is present.

This reaction takes place in the 'nucleus'.

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
9405375 Three transitions in the RNA polymerase II transcription complex during initiation. EMBO J 1998
Inferred Entries
Orthologous events