Plasmalogen biosynthesis (R-HSA-75896) [Homo sapiens]


1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organelle or associated with its membrane. These reactions are annotated here for palmityl (C16:0) CoA. In a series of less well-characterized reactions in the cytosol and endoplasmic reticulum, these molecules are converted to ether lipids (plasmalogens). The functions of plasmalogens are not well understood. They are an abundant subclass of phospholipids, however, and defects in their metabolism are associated with serious human disease (de Vet et al. 1999; Nagan and Zoeller 2001).

Locations in the PathwayBrowser
Additional Information
Compartment peroxisomal matrix
GO Biological Process ether lipid biosynthetic process (0008611)
Literature References
pubMedId Title Journal Year
11275267 Plasmalogens: biosynthesis and functions Prog Lipid Res 2001
10553003 Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities J Lipid Res 1999
Inferred Entries
Orthologous events