The RAD51-ssDNA nucleoprotein filament is a right-hand helical nucleoprotein filament referred to as the presynaptic filament. This nucleoprotein complex contains a binding site for the double-stranded homologous DNA molecule with which it interacts during strand exchange. Loading of RAD51 onto ssDNA is thought to be facilitated by recombination mediator RAD52 (McIlwraith et al., 2000), RAD51 paralogs: RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 (Sigurdsson et al., 2001), by the association of RAD52 with ssDNA (Parsons et al., 2000) and by the association of RAD51 with BRCA2 (Tarsounas et al., 2003).
|GO Biological Process||DNA recombinase assembly (0000730)|
|11459989||The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA.||Proc Natl Acad Sci U S A||2001|
|11751636||Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.||Genes Dev||2001|
|12606939||BRCA2-dependent and independent formation of RAD51 nuclear foci.||Oncogene||2003|
|10921897||Precise binding of single-stranded DNA termini by human RAD52 protein.||EMBO J||2000|
|11080452||Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins||J Mol Biol||2000|