Reactome: A Curated Pathway Database

Presynaptic phase of homologous DNA pairing and strand exchange (R-HSA-76003)

Species Homo sapiens

Summation

The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells Damage Surveillance and Repair (Keith Caldecott, editor) 2003