The tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment of others onto their surface leads to the formation of large platelet aggregates. The formation of a thrombus is strictly dependent on the formation of interplatelet bonds.
|BioModels Database||BIOMD0000000468, BIOMD0000000466, BIOMD0000000088, BIOMD0000000069, BIOMD0000000465, BIOMD0000000467|
|18174460||Cell adhesion mechanisms in platelets||Arterioscler Thromb Vasc Biol||2008|
|17585075||Adhesion mechanisms in platelet function||Circ Res||2007|