Reactome: A Curated Pathway Database

Platelet Aggregation (Plug Formation) (R-HSA-76009)

Species Homo sapiens


The tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment of others onto their surface leads to the formation of large platelet aggregates. The formation of a thrombus is strictly dependent on the formation of interplatelet bonds.

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000468, BIOMD0000000466, BIOMD0000000088, BIOMD0000000069, BIOMD0000000465, BIOMD0000000467
Literature References
pubMedId Title Journal Year
18174460 Cell adhesion mechanisms in platelets Arterioscler Thromb Vasc Biol 2008
17585075 Adhesion mechanisms in platelet function Circ Res 2007