Reactome: A Curated Pathway Database

Platelet Aggregation (Plug Formation)

Stable Identifier
R-HSA-76009
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment of others onto their surface leads to the formation of large platelet aggregates. The formation of a thrombus is strictly dependent on the formation of interplatelet bonds.

Literature References
PubMed ID Title Journal Year
17585075 Adhesion mechanisms in platelet function Circ Res 2007
18174460 Cell adhesion mechanisms in platelets Arterioscler Thromb Vasc Biol 2008
Participants
Participant Of
Orthologous Events
Cross References