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RNA Polymerase II Transcription Initiation And Promoter Clearance

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The transcription cycle is divided in three major phases: initiation, elongation, and termination. Transcription initiation include promoter DNA binding, DNA melting, and initial synthesis of short RNA transcripts. Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes the transition from initiation into transcript elongation. During this intermediate phase of transcription, contact with initiation factors is lost and stable association with the nascent transcript is established. These changes collectively comprise promoter clearance.

Literature References
PubMed ID Title Journal Year
22982364 Promoter clearance by RNA polymerase II Biochim. Biophys. Acta 2013
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