We will be undergoing a brief scheduled maintenance at Monday Jan 22 at 10AM EST - you may experience some outages

We will be undergoing a scheduled maintenance at Monday Jan 22 at 10AM EST

RNA Polymerase II Transcription Initiation And Promoter Clearance

Stable Identifier
R-HSA-76042
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The transcription cycle is divided in three major phases: initiation, elongation, and termination. Transcription initiation include promoter DNA binding, DNA melting, and initial synthesis of short RNA transcripts. Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes the transition from initiation into transcript elongation. During this intermediate phase of transcription, contact with initiation factors is lost and stable association with the nascent transcript is established. These changes collectively comprise promoter clearance.

Literature References
PubMed ID Title Journal Year
22982364 Promoter clearance by RNA polymerase II Biochim. Biophys. Acta 2013
Participants
Participant Of
Orthologous Events