Reactome: A Curated Pathway Database
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RNA Polymerase III Transcription Initiation From Type 1 Promoter

Stable Identifier
R-HSA-76061
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The type 1 promoters recruit TFIIIA, the founding member of the C2H2 zinc finger family of DNA-binding proteins (Engelke et al., 1980; Sakonju et al., 1981). The binding of TFIIIA then allows the binding of TFIIC (Lassar et al., 1983), a complex consisting of five subunits (which differs from the six subunits in S. cerevisiae) in human cells and S. pombe. Once the DNA/TFIIIA/TFIIIC complex is formed, Brf1-TFIIIB joins the complex and this in turn allows the recruitment of RNA polymerase III (Bieker et al., 1985; Setzer and Brown, 1985).

Literature References
Participants
Participant Of
Orthologous Events