Reactome: A Curated Pathway Database

RNA Polymerase III Transcription Initiation From Type 2 Promoter

Stable Identifier
R-HSA-76066
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The type 2 promoters can recruit TFIIIC without the help of TFIIIA because TFIIIC binds directly to the A and B boxes. As for the type 1 promoters, this then allows the binding of Brf1-TFIIIB and RNA polymerase III. Importantly, in the yeast system, once Brf1-TFIIIB has been recruited to type 1 or 2 promoters, TFIIIA and/or TFIIIC can be stripped from the DNA with high salt or heparin treatment. Brf1-TFIIIB remains bound to the DNA and is sufficient to direct multiple rounds of transcription .

Participants
Participant Of
Orthologous Events