Reactome: A Curated Pathway Database

CYP4A11 12-hydroxylates DDCX

Stable Identifier
R-HSA-76466
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
dodecanoic acid + O2 + NADPH + H+ -> 12-hydroxydodecanoic acid + H2O + NADP+
Locations in the PathwayBrowser
Summation

Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
oxygen binding activity of Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane] Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane] oxygen binding (0019825)
Orthologous Events
Cross References
Rhea