Reactome: A Curated Pathway Database

CYP4A11 12-hydroxylates DDCX (R-HSA-76466) [Homo sapiens]


Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.

Additional Information
Compartment smooth endoplasmic reticulum
GO Biological Process fatty acid metabolic process (0006631)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Cytochrome P450 (CYP4A11 based) oxygen binding (0019825)  
Cross References
Database Identifier
Rhea 38947, 38948
Literature References
pubMedId Title Journal Year
8914854 Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes Arch Biochem Biophys 1996