CYP4A11 12-hydroxylates DDCX

Stable Identifier
R-HSA-76466
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
dodecanoic acid + O2 + NADPH + H+ -> 12-hydroxydodecanoic acid + H2O + NADP+
Locations in the PathwayBrowser
Summation

Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.

Literature References
PubMed ID Title Journal Year
8914854 Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes Arch Biochem Biophys 1996
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events