Reactome: A Curated Pathway Database

Addition of nucleotides 10 and 11 on the growing transcript: Third Transition

Stable Identifier
R-HSA-76576
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Formation of phosphodiester bonds nine and ten creates RNA products, which do not dissociate from the RNA pol II initiation complex. The transcription complex has enter the productive elongation phase. TFIIH and ATP-hydrolysis are required for efficient promoter escape. The open region (‚??transcription bubble‚??) expands concomitant with the site of RNA-extension. The region upstream from the transcription start site (-9 to -3) collapses to the double-stranded state. TFIIH remains associated to the RNA pol II initiation complex.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
DNA-directed RNA polymerase activity of RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] DNA-directed RNA polymerase activity (0003899)
Orthologous Events