Reactome: A Curated Pathway Database

Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (R-HSA-76576)

Species Homo sapiens


Formation of phosphodiester bonds nine and ten creates RNA products, which do not dissociate from the RNA pol II initiation complex. The transcription complex has enter the productive elongation phase. TFIIH and ATP-hydrolysis are required for efficient promoter escape. The open region (â??transcription bubbleâ??) expands concomitant with the site of RNA-extension. The region upstream from the transcription start site (-9 to -3) collapses to the double-stranded state. TFIIH remains associated to the RNA pol II initiation complex.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Inferred Entries
Orthologous events