Reactome: A Curated Pathway Database

Phosphorylation (Ser5) of RNA pol II CTD (R-HSA-77071)

Species Homo sapiens


Phosphorylation of serine 5 residue at the CTD of pol II largest subunit is an important step signaling the end of initiation and escape into processive elongation processes. Cdk7 protein subunit of TFIIH phosphorylates RNA Pol II CTD serine 5 residues on its heptad repeats.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
TFIIH kinase activity (0016301)