Reactome: A Curated Pathway Database

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (R-HSA-77073)

Species Homo sapiens


The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
24354960 Cap-binding complex (CBC) Biochem. J. 2014