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Formation of the CE:GMP intermediate complex

Stable Identifier
R-HSA-77081
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A highly conserved lysine within the guanylyltransferase (GT) site of the mRNA capping enzyme attacks the alpha-phosphate of GTP. An enzyme-GMP covalent intermediate is formed.

Literature References
PubMed ID Title Journal Year
9512541 Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. Nucleic Acids Res 1998
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
mRNA guanylyltransferase activity of Capping complex (hydrolyzed) [nucleoplasm]
Physical Entity
Activity
Orthologous Events