Reactome: A Curated Pathway Database

Formation of the CE:GMP intermediate complex (R-HSA-77081) [Homo sapiens]


A highly conserved lysine within the guanylyltransferase (GT) site of the mRNA capping enzyme attacks the alpha-phosphate of GTP. An enzyme-GMP covalent intermediate is formed.

Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
Capping complex (hydrolyzed) mRNA guanylyltransferase activity (0004484)  
Literature References
pubMedId Title Journal Year
9512541 Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. Nucleic Acids Res 1998