Reactome: A Curated Pathway Database
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Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA

Stable Identifier
R-HSA-77083
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The diphosphate 5'-end of the mRNA is joined to the GMP, releasing it from the enzyme. At this time, it is unclear how the RNA diphosphate end is transferred from the active site of the triphosphatase to the guanylyltransferase site. The covalent enzyme-GMP complex can form in the absence of RNA.
Guanylyltransferase (GT) catalyzed second reaction can be represented as:ppN(pN)n + GTP -> GpppN(pN)n + PPi

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
mRNA guanylyltransferase activity of Capping complex (intermediate) [nucleoplasm] Capping complex (intermediate) [nucleoplasm] mRNA guanylyltransferase activity (0004484)
Orthologous Events