Reactome: A Curated Pathway Database

Methylation of GMP-cap by RNA Methyltransferase

Stable Identifier
R-HSA-77090
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the final step of the capping reaction, the methyltransferase takes a methyl group from S-adenosyl-methionine to the N7 position of the cap guanine. N7G-methyltransferase (MT) mediated reaction can be represented as:
GpppN(pN)n + S-adenosylmethionine (Adomet) ->m7GpppN(pN)n + S-adenosylhomocysteine (Adohcy).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
mRNA (guanine-N7-)-methyltransferase activity of Capping complex (with freed 5'- GMP) [nucleoplasm] Capping complex (with freed 5'- GMP) [nucleoplasm] mRNA (guanine-N7-)-methyltransferase activity (0004482)
Orthologous Events