Reactome: A Curated Pathway Database

Methylation of GMP-cap by RNA Methyltransferase (R-HSA-77090) [Homo sapiens]


In the final step of the capping reaction, the methyltransferase takes a methyl group from S-adenosyl-methionine to the N7 position of the cap guanine. N7G-methyltransferase (MT) mediated reaction can be represented as:
GpppN(pN)n + S-adenosylmethionine (Adomet) ->m7GpppN(pN)n + S-adenosylhomocysteine (Adohcy).

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
9790902 Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Biochem Biophys Res Commun 1998