Reactome: A Curated Pathway Database

Utilization of Ketone Bodies (R-HSA-77108)

Species Homo sapiens


The levels of acetone in ketone bodies are much lower than those of acetoacetic acid and beta-hydroxybutyric acid. Acetone cannot be converted back to acetyl-CoA, and is excreted in urine, or breathed out through the lungs. Extrahepatic tissues utilize ketone bodies by converting the beta-hydroxybutyrate successively to acetoacetate, acetoacetatyl-CoA, finally to acetyl-CoA (Sass 2011).

Locations in the PathwayBrowser
Additional Information
Compartment mitochondrial matrix
GO Biological Process ketone body catabolic process (0046952)
Literature References
pubMedId Title Journal Year
21479626 Inborn errors of ketogenesis and ketone body utilization J Inherit Metab Dis 2011