Reactome: A Curated Pathway Database
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mitochondrial fatty acid beta-oxidation of saturated fatty acids

Stable Identifier
R-HSA-77286
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once fatty acids have been imported into the mitochondrial matrix by the carnitine acyltransferases, the beta-oxidation spiral begins. Each turn of this spiral concludes with the repetitive removal of two carbon units from the fatty acyl chain. beta-oxidation of saturated fatty acids (fatty acids with even numbered carbon chains and no double bonds) involves four different enzymatic steps: oxidation, hydration, a second oxidation, and a concluding thiolysis step, resulting in the two-carbon acetyl-CoA and a newly CoA primed acyl-CoA for the next turn of the spiral.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed   2001
Participants
Participant Of
Orthologous Events