Reactome: A Curated Pathway Database

mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Stable Identifier
R-HSA-77288
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The complete beta-oxidation spiral produces and consumes intermediates with a trans configuration. Mitochondrial beta-oxidation of unsaturated fatty acids leads to intermediates not compatible with the four enzymatic steps responsible for the beta-oxidation of saturated fatty acids. Unsaturated fatty acids that have bonds in the cis configuration require three separate enzymatic steps to prepare these molecules for the beta-oxidation pathway. The further processing of these intermediates requires additional enzymes, depending on the position of the double bonds in the original fatty acids. Described here is the beta-oxidation of linoleoyl-CoA.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed   2001
Participants
Participant Of
Orthologous Events