Reactome: A Curated Pathway Database

TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (R-HSA-83582) [Homo sapiens]


Once formed in context of the TNFR1 signaling complex the TRADD:TRAF2:RIPK1 complex may dissociate from the TNF:TNFR1 platform. With the recruitment of FADD and caspase-8 to the TRADD:TRAF2:RIPK1 complex the cell is pushed along the apoptotic pathway provided that the protective FLIP protein and TRAF2-associated BIRC (cIAPs) do not inhibit caspase-8 activation by RIPK1 and RIPK3-mediated activation of the necroptotic pathway.

Additional Information
Compartment plasma membrane , cytosol