Reactome: A Curated Pathway Database
THIS SITE IS USED FOR RELEASE TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. (R-HSA-83582) [Homo sapiens]

Reaction
Summation

Once formed in context of the TNFR1 signaling complex the TRADD:TRAF2:RIPK1 complex may dissociate from the TNF:TNFR1 platform. With the recruitment of FADD and caspase-8 to the TRADD:TRAF2:RIPK1 complex the cell is pushed along the apoptotic pathway provided that the protective FLIP protein and TRAF2-associated BIRC (cIAPs) do not inhibit caspase-8 activation by RIPK1 and RIPK3-mediated activation of the necroptotic pathway.

Additional Information
Compartment plasma membrane , cytosol