Reactome: A Curated Pathway Database

phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks (R-HSA-83592)

Species Homo sapiens


At the beginning of this reaction, 1 molecule of 'MDC1/NFBD1:gamma-H2AX complex', and 1 molecule of 'phospho-ATM (Ser 1981)' are present. At the end of this reaction, 1 molecule of 'ATM associated with DNA double-strand break ends' is present.

This reaction takes place in the 'nucleus'.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm
Cross References
Database Identifier
IntAct IM-11070-1, EBI-495607, EBI-495489
Literature References
pubMedId Title Journal Year
12556884 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 2003