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ASC is recruited via a PYD-PYD interaction

Stable Identifier
R-HSA-844610
Type
Reaction
Species
Homo sapiens
Related Species
Staphylococcus aureus
Compartment
Locations in the PathwayBrowser
Summation

NLRP3 interacts with ASC (Manji et al. 2003) via their PYD domains (Dowds et al. 2004). NLRP3 oligomerization leads to PYD domain clustering which is believed to facilitate the interaction of NLRP3 with the PYD domain of ASC (Schroder & Tschopp, 2010).

Participants
Participant Of