Reactome: A Curated Pathway Database

ASC is recruited via a PYD-PYD interaction (R-HSA-844610) [Homo sapiens]


NLRP3 interacts with ASC (Manji et al. 2003) via their PYD domains (Dowds et al. 2004). NLRP3 oligomerization leads to PYD domain clustering which is believed to facilitate the interaction of NLRP3 with the PYD domain of ASC (Schroder & Tschopp, 2010).

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Compartment cytosol