Reactome: A Curated Pathway Database

The CARD domain of ASC recruits Procaspase-1 (R-HSA-844612)

Species Homo sapiens


Procaspase-1 is recruited via a CARD-CARD interaction with ASC. This creates procaspase-1 clustering which is believed to stimulate procaspase-1 autocleavage, generating the p10/p20 fragments that assemble into the active capsase-1 tetramer (Schroder & Tschopp, 2010).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol