Reactome: A Curated Pathway Database

USP9X (FAM) deubiquitinates SMAD4 (R-HSA-870437) [Homo sapiens]


USP9X (FAM) deubiquitinates SMAD4, thereby opposing the negative regulatory activity of TRIM33 (Ectodermin) (Dupont et al. 2009).

Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
Ub-SMAD4:USP9X thiol-dependent ubiquitin-specific protease activity (0004843)
Literature References
pubMedId Title Journal Year
19135894 FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Cell 2009