Reactome | USP9X (FAM) deubiquitinates SMAD4

USP9X (FAM) deubiquitinates SMAD4

Stable Identifier

R-HSA-870437

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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USP9X (FAM) deubiquitinates SMAD4, thereby opposing the negative regulatory activity of TRIM33 (Ectodermin) (Dupont et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19135894	FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Stinchfield, MJ, Montagner, M, Morsut, L, Piccolo, S, Inui, M, Moro, S, Mamidi, A, Newfeld, SJ, Soligo, S, Dupont, S, Argenton, F, Martello, G, Modena, N, Adorno, M, Zacchigna, L, Cordenonsi, M	Cell	2009