TRIM33 monoubiquitinates SMAD4

Stable Identifier
R-HSA-870449
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) monoubiquitinates nuclear SMAD4 on lysine residue K519. This leads to disruption of heterotrimeric complexes composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3). TRIM33 inhibits SMAD activity without affecting steady state levels of SMAD4 (Dupont et al. 2009, Dupont et al. 2005).

Literature References
PubMed ID Title Journal Year
15820681 Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

Dupont, S, Zacchigna, L, Cordenonsi, M, Soligo, S, Adorno, M, Rugge, M, Piccolo, S

Cell 2005
19135894 FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

Dupont, S, Mamidi, A, Cordenonsi, M, Montagner, M, Zacchigna, L, Adorno, M, Martello, G, Stinchfield, MJ, Soligo, S, Morsut, L, Inui, M, Moro, S, Modena, N, Argenton, F, Newfeld, SJ, Piccolo, S

Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed