Reactome: A Curated Pathway Database

TRIM33 monoubiquitinates SMAD4

Stable Identifier
R-HSA-870449
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) monoubiquitinates nuclear SMAD4 on lysine residue K519. This leads to disruption of heterotrimeric complexes composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3). TRIM33 inhibits SMAD activity without affecting steady state levels of SMAD4 (Dupont et al. 2009, Dupont et al. 2005).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm] p-SMAD2/3:SMAD4:TRIM33 [nucleoplasm] ubiquitin-protein transferase activity (0004842)
Orthologous Events