Reactome: A Curated Pathway Database

TRIM33 monoubiquitinates SMAD4 (R-HSA-870449) [Homo sapiens]


TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) monoubiquitinates nuclear SMAD4 on lysine residue K519. This leads to disruption of heterotrimeric complexes composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3). TRIM33 inhibits SMAD activity without affecting steady state levels of SMAD4 (Dupont et al. 2009, Dupont et al. 2005).

Additional Information
Compartment nucleoplasm
Catalyst Activity
PhysicalEntity Activity Active Units
p-SMAD2/3:SMAD4:TRIM33 ubiquitin-protein transferase activity (0004842)