TRIM33 monoubiquitinates SMAD4
Species Homo sapiens
TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) monoubiquitinates nuclear SMAD4 on lysine residue K519. This leads to disruption of heterotrimeric complexes composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3). TRIM33 inhibits SMAD activity without affecting steady state levels of SMAD4 (Dupont et al. 2009, Dupont et al. 2005).
Locations in the PathwayBrowser
Signal Transduction(Homo sapiens)
Gene Expression(Homo sapiens)