Reactome: A Curated Pathway Database
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Transphosphorylation of JAK1

Stable Identifier
R-HSA-873918
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The initial phosphorylation of JAK1 and JAK2 is mediated by JAK2. Autophosphorylated JAK2 may transphopshorylate JAK1 bound to IFNGR1 chain. Tyrosine 1033 in the activation loop of the JAK1 kinase domain may be the target for transphosphorylation (phosphorylation site mentioned here is based on sequence similarity with all the other JAK kinases).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events