Reactome: A Curated Pathway Database

Transphosphorylation of JAK1 (R-HSA-873918)

Species Homo sapiens

Summation

The initial phosphorylation of JAK1 and JAK2 is mediated by JAK2. Autophosphorylated JAK2 may transphopshorylate JAK1 bound to IFNGR1 chain. Tyrosine 1033 in the activation loop of the JAK1 kinase domain may be the target for transphosphorylation (phosphorylation site mentioned here is based on sequence similarity with all the other JAK kinases).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 protein tyrosine kinase activity (0004713)
This entry is regulated by
Regulation type Name
NegativeRegulation