Reactome: A Curated Pathway Database
Attention
The EBI data centre will be shutting down from the afternoon (BST) of Friday 26th August until the afternoon of Tuesday 30th August 2016 for essential maintenance. This might have an impact on some Reactome services and we apologize for any inconvenience.

Phosphorylation of JAK2

Stable Identifier
R-HSA-873919
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

IFN-gamma binding to the receptor complex, induces JAK2 autophosphorylation and activation. Like all protein tyrosine kinases (PTKs) JAK2 activity also depends on the phosphorylation of tandem tyrosine residues within the activation loop that results in the removal of the activation loop from the active site. Multiple phosphorylation sites have been identified in JAK2 (tyrosines 221, 570, 868, 966, 972, 1007 and 1008 ) of which phosphorylation of tyrosine 1007 is essential for kinase activity. Tyrosine 1007 is in the activation loop and phosphorylation allows access of the catalytic loop to the ATP in the ATP binding domain. Of all the predicted phoshorylation sites only tyrosine 1007 is represented in the reaction.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events