Binding of STAT1 to p-IFNGR1

Stable Identifier
R-HSA-873921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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General
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The phosphorylated tyrosine residue 440 in the 440YDKPH444 motif on IFNGR1 chain serves as a docking site and recruits STAT1, an SH2 domain-containing transcription factor to the functional receptor unit.
Literature References
PubMed ID Title Journal Year
8156998 Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)

Greenlund, AC, Schreiber, RD, Viviano, BL, Farrar, MA

EMBO J 1994
7796299 Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process

Krolewski, J, Morales, MO, Greenlund, AC, Yan, H, Schreiber, RD, Viviano, BL

Immunity 1995
12040185 A road map for those who don't know JAK-STAT

Horvath, CM, Aaronson, DS

Science 2002
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