STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.
|STAT1 bound to p-IFNGR1||protein tyrosine kinase activity (0004713)|
|7690989||A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma||Science||1993|
|7657660||Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor||J Biol Chem||1995|
|8631301||Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state||EMBO J||1996|
|12040185||A road map for those who don't know JAK-STAT||Science||2002|