Reactome: A Curated Pathway Database

Phoshorylation of STAT1 by JAK kinases

Stable Identifier
R-HSA-873922
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane] STAT1 bound to p-IFNGR1 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events