Reactome: A Curated Pathway Database

Phoshorylation of STAT1 by JAK kinases (R-HSA-873922) [Homo sapiens]


STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
STAT1 bound to p-IFNGR1 protein tyrosine kinase activity (0004713)