Reactome: A Curated Pathway Database

Phosphorylation of IFNGR1 by JAK kinases (R-HSA-873924) [Homo sapiens]


The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 protein tyrosine kinase activity (0004713)