Reactome: A Curated Pathway Database

Phosphorylation of IFNGR1 by JAK kinases (R-HSA-873924)

Species Homo sapiens

Summation

The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 protein tyrosine kinase activity (0004713)