Phosphorylation of IFNGR1 by JAK kinases

Stable Identifier
R-HSA-873924
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events