Reactome: A Curated Pathway Database
THIS SITE IS USED FOR RELEASE TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Phosphorylation of IFNGR1 by JAK kinases (R-HSA-873924) [Homo sapiens]

Reaction
Summation

The phosphorylated active JAK1 kinase inturn phosphorylates tyrosine residue 440 on each of the IFNGR1 chains to form two adjacent docking sites for the latent STAT1 SH2 domains.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 protein tyrosine kinase activity (0004713)