Reactome: A Curated Pathway Database

Release of STAT1 dimer from active receptor unit (R-HSA-873927) [Homo sapiens]


The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.

Additional Information
Compartment cytosol , plasma membrane