Reactome: A Curated Pathway Database

Release of STAT1 dimer from active receptor unit

Stable Identifier
R-HSA-873927
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.

Literature References
Participants
Participant Of
Orthologous Events