Reactome: A Curated Pathway Database

SOCS-1 and SOCS-3 binds to p-JAK2

Stable Identifier
R-HSA-877269
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SOCS-1 and SOCS-3 coprecipitates with JAK kinases upon IFNG stimulation and are able to inhibit the JAK-STAT pathway, although with different affinity and kinetics. SOCS1 and SOCS3 binds to phosphorylated JAK1/2 and prevent the tyrosine kinase activity of JAKs through their kinase inhibitory region (KIR), thereby inhibiting downstream IFNG signaling. SOCS1 may also prevent IFNG signaling by targeting the signaling machinery to ubiquitin-proteasomal degradation pathway.

Literature References
Participants
Participant Of
Orthologous Events