Reactome: A Curated Pathway Database

Dephosphorylation of JAKs by PTPs (R-HSA-877308)

Species Homo sapiens


Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
PTPs-SHP1/2/PTP1B protein tyrosine phosphatase activity (0004725)
Inferred Entries
Inferred From