Reactome: A Curated Pathway Database

Dephosphorylation of JAKs by PTPs

Stable Identifier
R-HSA-877308
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of PTPs-SHP1/2/PTP1B [cytosol] PTPs-SHP1/2/PTP1B [cytosol] protein tyrosine phosphatase activity (0004725)
Inferred From